一种新的锌基质金属蛋白酶抑制剂阿吉拉汀A的全合成方法，其具有生物生源模式的6π-2-氮杂三烯电环化反应。

A new total synthesis of the zinc matrixmetalloproteinase inhibitor ageladine A featuring a biogenetically patterned 6pi-2-azatriene electrocyclization.

作者信息

Meketa Matthew L, Weinreb Steven M

机构信息

Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

出版信息

Org Lett. 2007 Mar 1;9(5):853-5. doi: 10.1021/ol063038a. Epub 2007 Jan 30.

DOI:10.1021/ol063038a

PMID:17261003

Abstract

[reaction: see text] A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6pi-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety.

摘要

[反应：见正文] 通过使用受生物启发的6π-2-氮杂三烯电环化反应作为形成咪唑并吡啶部分的关键步骤，实现了杂环海洋海绵代谢产物阿吉拉定A的第二代汇聚式全合成。