Groenendaal Bas, Ruijter Eelco, Orru Romano V A
Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.
Chem Commun (Camb). 2008 Nov 21(43):5474-89. doi: 10.1039/b809206k. Epub 2008 Sep 8.
1-Azadienes are versatile building blocks for the efficient construction of various N-heterocycles. Depending on the substitution pattern and reaction partner, they may participate in a range of different reactions. An overview of recent methods for the generation of 1-azadienes is presented, as well as their application in cycloaddition, electrocyclization, and multicomponent reactions. Considering the broad range of reactivities and resulting heterocyclic scaffold structures, 1-azadienes are very useful reactive intermediates for the development of modular reaction sequences in diversity-oriented synthesis.
1-氮杂二烯是用于高效构建各种氮杂环的多功能构件。根据取代模式和反应伙伴的不同，它们可参与一系列不同的反应。本文综述了近期生成1-氮杂二烯的方法，以及它们在环加成、电环化和多组分反应中的应用。鉴于1-氮杂二烯具有广泛的反应活性以及由此产生的杂环骨架结构，它们是用于在多样性导向合成中开发模块化反应序列的非常有用的反应中间体。
