Basnar Bernhard, Xu Jianping, Li Di, Willner Itamar
Institute of Chemistry and the Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Langmuir. 2007 Feb 27;23(5):2293-6. doi: 10.1021/la063185h. Epub 2007 Jan 30.
A C18 monolayer-functionalized Si surface is electrochemically patterned to yield a carboxylic acid-terminated pattern. Tyramine is covalently linked to the pattern to yield an encoded nanostructure for the enzyme tyrosinase. The biocatalytic oxidation of the tyramine residues yields catechol moieties that control the assembly of boronic acid-functionalized Au nanoparticles (NPs) or magnetic NPs. The different NPs are linked to the patterns by the formation of complexes between the boronic acid residues or Fe3+ ions and the catechol ligands.
将C18单分子层功能化的硅表面进行电化学图案化处理，以产生羧酸封端的图案。将酪胺共价连接到该图案上，以产生用于酪氨酸酶的编码纳米结构。酪胺残基的生物催化氧化产生儿茶酚部分，其控制硼酸功能化的金纳米颗粒（NP）或磁性NP的组装。不同的NP通过硼酸残基或Fe3+离子与儿茶酚配体之间形成络合物而与图案相连。
