Svestka Jaromir, Bitter Istvan
Department of Psychiatry, Masaryk University Komenskeho namesti 220/2, 602 00 Brno-mesto, Czech Republic.
Neuro Endocrinol Lett. 2007 Feb;28 Suppl 1:95-116.
Adherence to treatment is a general indicator of quality and success of communication between the physician and the patient. It means the extent to which patient behaviour, in terms of taking medications, following diets, or executing life-style changes, coincides with medical or health advice. Nonadherence to antipsychotic therapy in patients with schizophrenia is far more widespread than clinicians assume. Lower nonadherence in therapy based on antipsychotics of the second generation compared with conventional medications has already been indicated by early reports. The consequences of nonadherence include exacerbation of symptoms, an increased relapse rate, psychiatric hospitalization hospitalisation, and less favourable patient prognosis. There are several factors that cause treatment nonadherence in schizophrenia: causes derived from the schizophrenic disorder itself, patient characteristics, causes associated associated with the health-care system, and the antipsychotic treatment itself.
坚持治疗是医生与患者之间沟通质量和成功与否的一项总体指标。它指的是患者在服药、遵循饮食或进行生活方式改变方面的行为与医疗或健康建议相符的程度。精神分裂症患者不坚持抗精神病治疗的情况远比临床医生所认为的更为普遍。早期报告已表明，与传统药物相比，第二代抗精神病药物治疗的不依从性较低。不坚持治疗的后果包括症状加重、复发率增加、精神科住院治疗以及患者预后较差。导致精神分裂症治疗不依从的因素有几个：源于精神分裂症本身的原因、患者特征、与医疗保健系统相关的原因以及抗精神病治疗本身。
