羊角拗中的吲哚生物碱。

Indole Alkaloids from Alstonia angustifolia.

机构信息

Organisch-chemisches Institut der Universität Zürich, Winterthurerstraße 190, CH-8057 Zürich, Switzerland.

出版信息

Planta Med. 1989 Oct;55(5):463-6. doi: 10.1055/s-2006-962065.

DOI:10.1055/s-2006-962065

Abstract

From the stem bark of ALSTONIA ANGUSTIFOLIA, eleven alkaloids were isolated. Seven of them are known ones: echitamine ( 1), N(b)-demethylechitamine ( 2), pseudoakuammigine ( 3), tubotaiwine ( 5), akuammicine ( 6), N(b)-beta-methylantirhine ( 12), and N(b)-methylakuammidine ( 13). The four others, pseudoakuammigine N-oxide ( 4), akuammicine N-oxide ( 7), N(b)-demethylalstogustine ( 8), and N(b)-demethylalstogustine N-oxide ( 11), are new alkaloids. Their structures were determined by means of spectroscopic analysis and chemical correlation with known alkaloids.

摘要

从 ALSTONIA ANGUSTIFOLIA 的茎皮中分离得到了 11 种生物碱。其中 7 种为已知生物碱：echitamine（1）、N(b)-demethylechitamine（2）、pseudoakuammigine（3）、tubotaiwine（5）、akuammicine（6）、N(b)-beta-methylantirhine（12）和 N(b)-methylakuammidine（13）。另外 4 种为新生物碱：pseudoakuammigine N-oxide（4）、akuammicine N-oxide（7）、N(b)-demethylalstogustine（8）和 N(b)-demethylalstogustine N-oxide（11）。这些结构通过光谱分析和与已知生物碱的化学相关性来确定。