菲律宾鸡骨常山叶片中的吲哚生物碱。

Indole alkaloids from the leaves of Philippine Alstonia scholaris.

作者信息

Macabeo Allan Patrick G, Krohn Karsten, Gehle Dietmar, Read Roger W, Brophy Joseph J, Cordell Geoffrey A, Franzblau Scott G, Aguinaldo Alicia M

机构信息

Phytochemistry Laboratory, Research Center for the Natural Sciences, Thomas Aquinas Research Complex, University of Santo Tomas, Espana St., Manila 1008, Philippines.

出版信息

Phytochemistry. 2005 May;66(10):1158-62. doi: 10.1016/j.phytochem.2005.02.018.

DOI:10.1016/j.phytochem.2005.02.018

PMID:15924920

Abstract

The first seco-uleine alkaloids, manilamine (1) (18-hydroxy-19,20-dehydro-7,21-seco-uleine) and N4-methyl angustilobine B (2), were isolated from the (pH 5) alkaloid extract of Philippine Alstonia scholaris leaves together with the known indole alkaloids 19,20-(E)-vallesamine (3), angustilobine B N4-oxide (4), 20(S)-tubotaiwine (5), and 6,7-seco-angustilobine B (6). The structure of the alkaloids was established from MS and NMR experiments.

摘要

从菲律宾鸡骨常山叶子的（pH 5）生物碱提取物中分离出了首批裂乌灵碱生物碱，马尼拉胺（1）（18-羟基-19,20-脱氢-7,21-裂乌灵碱）和N4-甲基狭叶罗平碱B（2），以及已知的吲哚生物碱19,20-(E)-瓦勒萨明（3）、狭叶罗平碱B N4-氧化物（4）、20(S)-图波台文（5）和6,7-裂狭叶罗平碱B（6）。通过质谱和核磁共振实验确定了这些生物碱的结构。