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α2肾上腺素能受体激动剂

Alpha2-adrenoceptor agonists.

作者信息

Sanders Robert D, Maze Mervyn

机构信息

Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.

出版信息

Curr Opin Investig Drugs. 2007 Jan;8(1):25-33.

PMID:17263182
Abstract

Alpha2-Adrenoceptor agonists have an immensely diverse utility in peri-operative and critical care medicine. In particular, their application as premedicants, analgesics and hypnotics/sedatives is becoming increasingly popular with delivery to a wide spectrum of patients. The ability of these agents to provide renal, cardiac and neurocognitive protection is only just being realized and requires further study.

摘要

α2肾上腺素能受体激动剂在围手术期和重症监护医学中有着极为广泛的用途。特别是,它们作为术前用药、镇痛药和催眠药/镇静药的应用在各类患者中的使用越来越普遍。这些药物提供肾脏、心脏和神经认知保护的能力才刚刚被认识到,还需要进一步研究。

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Alpha2-adrenoceptor agonists.α2肾上腺素能受体激动剂
Curr Opin Investig Drugs. 2007 Jan;8(1):25-33.
2
Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient.α2肾上腺素能受体激动剂的围手术期应用与心脏病人
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Treating agitation with dexmedetomidine in the ICU.在重症监护病房使用右美托咪定治疗躁动。
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Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics.右美托咪定对小儿骶管阻滞中布比卡因特性的影响。
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The role of alpha2-agonists in neurosurgery.α2激动剂在神经外科手术中的作用。
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Anesthetic management of a pituitary tumor resection with dexmedetomidine.右美托咪定用于垂体瘤切除术的麻醉管理
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[Clonidine and anesthesia].[可乐定与麻醉]
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引用本文的文献

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Comparative Efficacy of Dexmedetomidine and Remifentanil in Reducing Postoperative Pain and Opioid Use: A Systematic Review.右美托咪定与瑞芬太尼在减轻术后疼痛及减少阿片类药物使用方面的疗效比较:一项系统评价
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The effects of dexmedetomidine on liver injury in rats with experimental sepsis: A histopathological and immunohistochemical study.右美托咪定对实验性脓毒症大鼠肝损伤的影响:一项组织病理学和免疫组织化学研究。
Ulus Travma Acil Cerrahi Derg. 2025 Feb;31(2):112-118. doi: 10.14744/tjtes.2025.55338.
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Effect of dexmedetomidine on pulmonary function in obese patients undergoing laparoscopic surgery.
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4
Dexmedetomidine Protects Cortical Neurons from Propofol-Induced Apoptosis via Activation of Akt-IKK-NF-κB Signaling Pathway by α-adrenoceptor.右美托咪定通过α肾上腺素受体激活 Akt-IKK-NF-κB 信号通路保护皮质神经元免受异丙酚诱导的细胞凋亡。
Appl Biochem Biotechnol. 2024 Aug;196(8):4849-4861. doi: 10.1007/s12010-023-04768-4. Epub 2023 Nov 18.
5
The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial.右美托咪定对感染性休克患者血管加压素需求的影响:镇静实践在重症监护评估 [SPICE III] 试验的亚组分析。
Crit Care. 2020 Jul 16;24(1):441. doi: 10.1186/s13054-020-03115-x.
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Comparison of Intravenous Dexmedetomidine versus Esmolol for Attenuation of Hemodynamic Response to Tracheal Intubation after Rapid Sequence Induction: A Systematic Review and Meta-Analysis.静脉注射右美托咪定与艾司洛尔对快速序贯诱导后气管插管时血流动力学反应的抑制作用比较:系统评价和荟萃分析。
Biomed Res Int. 2019 Apr 17;2019:6791971. doi: 10.1155/2019/6791971. eCollection 2019.
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A Comparative Study on Efficacy and Safety of Propofol versus Dexmedetomidine in Sleep Apnea Patients undergoing Drug-Induced Sleep Endoscopy: .丙泊酚与右美托咪定在睡眠呼吸暂停患者药物诱导睡眠内镜检查中疗效和安全性的对比研究: 。
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8
Does remifentanil attenuate renal ischemia-reperfusion injury better than dexmedetomidine in rat kidney?在大鼠肾脏中,瑞芬太尼在减轻肾缺血再灌注损伤方面是否比右美托咪定更有效?
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10
Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats.右美托咪定抑制大鼠原位自体肝移植后TLR4/NF-κB激活并减轻急性肾损伤。
Sci Rep. 2015 Nov 20;5:16849. doi: 10.1038/srep16849.