Tron'ko N D, Pushkarev V M, Chelnakova I S, Iarovaia L V, Mikosha A S
Fiziol Zh (1978). 1991 Nov-Dec;37(6):55-60.
Influence of Ca2+ channel modulators BAY K 8644, nitrendipine and newly synthesized derivative of 1,4-dihydropyridine: 4-(3', 4'-dimethoxyphenyl)-2,6-dimethyl-3,5- diethoxy-carbonyl-1,4-dihydropyridine-(DHP-51) on aldosterone production by adrenocortical slices depends on K+ content in the incubation medium. The modulators only slightly influence the hormone output at low K+ level in the medium. Intensive synthesis of aldosterone at high level of potassium in the medium was prevented in the presence of DHP-51 and low concentration of BAY K 8644. DHP-51 inhibited [3H]-cholesterol incorporation into all main corticosteroids in the high-potassium medium.
钙通道调节剂BAY K 8644、尼群地平和新合成的1,4-二氢吡啶衍生物：4-(3',4'-二甲氧基苯基)-2,6-二甲基-3,5-二乙氧羰基-1,4-二氢吡啶-(DHP-51)对肾上腺皮质切片醛固酮生成的影响取决于孵育培养基中的钾含量。这些调节剂在培养基低钾水平时仅对激素分泌有轻微影响。在DHP-51和低浓度BAY K 8644存在的情况下，培养基中高钾水平时醛固酮的大量合成受到抑制。DHP-51在高钾培养基中抑制了[3H]-胆固醇掺入所有主要皮质类固醇中。
