Vinje Jo, Sletten Einar
Department of Chemistry, University of Bergen, Bergen, Norway.
Anticancer Agents Med Chem. 2007 Jan;7(1):35-54. doi: 10.2174/187152007779313982.
The focus of this review is on recently published papers (2000-2005) where NMR spectroscopy has been applied as the principal method in the study of anticancer platinum drugs. The paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum compounds and nucleic acid constituents. The latest NMR studies on the well-known anticancer drug cisplatin, with focus on kinetics and cisplatin-DNA structures are reported. Also cisplatin analogues clinically approved or currently in clinical trials are discussed. In addition two new classes of anticancer platinum drugs are described: trans-oriented Pt iminoether complexes and multinuclear Pt complexes. Reaction kinetics and structural changes induced by these novel Pt drugs are discussed in relation to cisplatin. NMR studies of non-DNA platinum drug targets including peptides, proteins and phospholipid membranes are also treated.
本综述的重点是最近发表的论文（2000 - 2005年），其中核磁共振光谱法已被用作研究抗癌铂类药物的主要方法。本文概述了与研究铂化合物和核酸成分之间相互作用特别相关的基本核磁共振技术。报道了对著名抗癌药物顺铂的最新核磁共振研究，重点是动力学和顺铂 - DNA结构。还讨论了临床批准或目前正在临床试验中的顺铂类似物。此外，还描述了两类新型抗癌铂类药物：反式取向的铂亚氨基醚配合物和多核铂配合物。讨论了这些新型铂类药物相对于顺铂所引起的反应动力学和结构变化。还涉及了对非DNA铂类药物靶点（包括肽、蛋白质和磷脂膜）的核磁共振研究。
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