Ronconi Luca, Sadler Peter J
School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK.
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Coord Chem Rev. 2008 Nov;252(21):2239-2277. doi: 10.1016/j.ccr.2008.01.016. Epub 2008 Jan 26.
There is a wide range of potential applications of inorganic compounds, and metal coordination complexes in particular, in medicine but progress is hampered by a lack of methods to study their speciation. The biological activity of metal complexes is determined by the metal itself, its oxidation state, the types and number of coordinated ligands and their strength of binding, the geometry of the complex, redox potential and ligand exchange rates. For organic drugs a variety of readily observed spin = 1/2 nuclei can be used (H, C, N, F, P), but only a few metals fall into this category. Most are quadrupolar nuclei giving rise to broad lines with low detection sensitivity (for biological systems). However we show that, in some cases, heteronuclear NMR studies can provide new insights into the biological and medicinal chemistry of a range of elements and these data will stimulate further advances in this area.
无机化合物，尤其是金属配位络合物，在医学领域有广泛的潜在应用，但由于缺乏研究其形态的方法，进展受到阻碍。金属络合物的生物活性由金属本身、其氧化态、配位配体的类型和数量及其结合强度、络合物的几何形状、氧化还原电位和配体交换速率决定。对于有机药物，可以使用多种易于观察的自旋=1/2核（H、C、N、F、P），但只有少数金属属于这一类。大多数是四极核，会产生宽谱线且检测灵敏度低（对于生物系统）。然而，我们表明，在某些情况下，异核核磁共振研究可以为一系列元素的生物和药物化学提供新的见解，这些数据将推动该领域的进一步发展。
