神经毒性朊病毒蛋白（PrP）片段106 - 126在缺乏PrP的神经元细胞系中需要PrP疏水区域的N端一半。
Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line.
作者信息
Sakudo Akikazu, Nakamura Izuru, Lee Deug-Chan, Saeki Keiichi, Ikuta Kazuyoshi, Onodera Takashi
机构信息
Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
出版信息
Protein Pept Lett. 2007;14(1):1-6.
The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.
使用永生化朊病毒蛋白（PrP）基因缺陷型神经元细胞系检测老化型PrP(106 - 126)的细胞毒性。老化型PrP(106 - 126)的神经毒性需要PrP疏水区域（HR）的N端一半而非八肽重复序列（OR），这表明老化型PrP(106 - 126)的神经毒性信号由该区域介导。
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