Lai P K, Tamura Y, Bradley W G, Donovan J, Tanaka A, Nonoyama M
Laboratory of Virology, Tampa Bay Research Institute, St Petersburg, FL 33716.
Int J Immunopharmacol. 1991;13 Suppl 1:55-61. doi: 10.1016/0192-0561(91)90125-q.
The remarkable ability of HIV to insinuate itself into the working of the immune system is the key of its success as an infectious agent. Given that the cytokine network regulates the immune responses, it is not surprising that cytokines can modulate HIV infection. GM-CSF, IL6 and TNF-alpha enhance HIV, but TGF-beta and HIF inhibits the virus. However, the anti-HIV activity of TGF-beta is restricted to myeloid cells, while HIF inhibits HIV in myeloid cells and in T-lymphocytes. HIF is produced by CEM cells after induction by an extract from pine cones. It is not an interferon and is likely a novel cytokine. It is pepsin-sensitive but trypsin-resistant and has an apparent molecular weight of 7-12 KDa. Apart from having anti-HIV activity, crude preparations of HIF also inhibit HTLV-1 virus but not HSV virus replication.
人类免疫缺陷病毒（HIV）具有非凡的能力，能够潜入免疫系统的运作过程，这是它作为一种传染因子取得成功的关键。鉴于细胞因子网络调节免疫反应，细胞因子能够调节HIV感染也就不足为奇了。粒细胞-巨噬细胞集落刺激因子（GM-CSF）、白细胞介素6（IL6）和肿瘤坏死因子-α（TNF-α）能增强HIV感染，而转化生长因子-β（TGF-β）和低氧诱导因子（HIF）则抑制该病毒。然而，TGF-β的抗HIV活性仅限于髓样细胞，而HIF在髓样细胞和T淋巴细胞中均能抑制HIV。松果体提取物诱导后，CEM细胞会产生HIF。它不是干扰素，可能是一种新型细胞因子。它对胃蛋白酶敏感，但对胰蛋白酶有抗性，表观分子量为7-12千道尔顿。除了具有抗HIV活性外，HIF的粗制品还能抑制人类嗜T细胞病毒1型（HTLV-1）病毒，但不抑制单纯疱疹病毒（HSV）的复制。
