形态发生素作为保守的轴突导向信号

Morphogens as conserved axon guidance cues.

作者信息

Zou Yimin, Lyuksyutova Anna I

机构信息

Biological Sciences Division Neurobiology Section, University of California, San Diego, 9500 Gilman Drive, Pacific Hall - Room 1220, La Jolla, California 92093, USA.

出版信息

Curr Opin Neurobiol. 2007 Feb;17(1):22-8. doi: 10.1016/j.conb.2007.01.006. Epub 2007 Jan 30.

DOI:10.1016/j.conb.2007.01.006

PMID:17267201

Abstract

Morphogen family proteins are now widely appreciated as axon guidance cues. Because their roles as morphogens are highly conserved across phylogeny, their functional conservation in axon guidance is now being rigorously examined. Recent studies suggest that morphogens are important in shaping topographic projections in chick and Drosophila visual systems, a process that occurs even later in development.

摘要

形态发生素家族蛋白如今被广泛认为是轴突导向信号。由于它们作为形态发生素的作用在系统发育中高度保守，其在轴突导向中的功能保守性正受到严格审视。最近的研究表明，形态发生素在塑造鸡和果蝇视觉系统中的拓扑投射方面很重要，这一过程甚至在发育后期才会发生。