Schmidt R, Oestreich W
Medical Department, Janssen GmbH, Neuss, Germany.
J Cardiovasc Pharmacol. 1991;18 Suppl 8:S27-30.
Because maintenance antivertiginous treatment with commonly used drugs is only moderately effective, there is still need for new therapeutic concepts in the therapy of vestibular vertigo. The cerebral calcium antagonist flunarizine (Sibelium) revealed positive vestibular effects in experimental animal studies and in healthy volunteers. Clinical trials versus placebo and reference drugs proved flunarizine to be effective in the treatment of vestibular disorders. Somnolence, weight gain, and, in rare cases, extrapyramidal symptoms and depression were discussed as side effects. Further studies on flunarizine's mechanism of action are needed to elucidate whether its clinical effects are indeed due to calcium-entry blockade.
由于使用常用药物进行的维持性抗眩晕治疗效果仅为中等，因此在前庭性眩晕的治疗中仍需要新的治疗理念。脑钙拮抗剂氟桂利嗪（西比灵）在实验动物研究和健康志愿者中显示出积极的前庭效应。与安慰剂和对照药物的临床试验证明氟桂利嗪在治疗前庭疾病方面有效。嗜睡、体重增加以及罕见的锥体外系症状和抑郁被认为是副作用。需要对氟桂利嗪的作用机制进行进一步研究，以阐明其临床效果是否确实归因于钙内流阻断。
