Szela S
Oddziału Wewnetrznego B Wojewódzkiego Szpitala Zespolonego, Wrocławiu.
Acta Haematol Pol. 1991;22(2):303-9.
In various anaemias the values of 8 acute phase factors were determined simultaneously before and at the end of treatment: seromucoid, sialic acid, acid alpha 1-glycoprotein, alpha 1-antitrypsin, haptoglobin, ceruloplasmin, transferrin and fibrinogen. In iron-deficiency anaemia without coexistent inflammatory changes in organs the levels of 4 proteins--seromucoid, alpha 1-antitrypsin, ceruloplasmin and transferrin, were consistently raised. In iron-deficiency anemia with concomitant infection 4 proteins also were increased, but in place of alpha 1-antitrypsin the haptoglobin level was raised. In megaloblastic anaemia the ceruloplasmin level was increased, and in haemolytic anaemia one factor--sialic acid--was decreased. At the end of treatment the concentrations of certain proteins were changed depending on their specific role in various forms of anaemia and on various additional factors. In iron-deficiency anaemia without coexistent infection the concentration of seromucoid was decreased, and in this anaemia with coexistent infection alpha 1-antitrypsin, haptoglobin, and fibrinogen levels were raised, in haemolytic anaemia only fibrinogen was increased, and megaloblastic anaemia was associated with raised seromucoid level. The therapeutic result was good in all these anaemias with the exception of iron-deficiency anaemia associated with infection in which it was less propitious.
在各种贫血中，于治疗前及治疗结束时同时测定8种急性期因子的值：血清类黏蛋白、唾液酸、酸性α1-糖蛋白、α1-抗胰蛋白酶、触珠蛋白、铜蓝蛋白、转铁蛋白和纤维蛋白原。在不存在器官并存炎症变化的缺铁性贫血中，4种蛋白质——血清类黏蛋白、α1-抗胰蛋白酶、铜蓝蛋白和转铁蛋白的水平持续升高。在伴有感染的缺铁性贫血中，4种蛋白质也升高，但触珠蛋白水平升高以取代α1-抗胰蛋白酶。在巨幼细胞贫血中，铜蓝蛋白水平升高，而在溶血性贫血中，一个因子——唾液酸——降低。治疗结束时，某些蛋白质的浓度根据它们在各种贫血形式中的特定作用以及各种其他因素而发生变化。在不存在并存感染的缺铁性贫血中，血清类黏蛋白浓度降低，而在伴有并存感染的这种贫血中，α1-抗胰蛋白酶、触珠蛋白和纤维蛋白原水平升高，在溶血性贫血中仅纤维蛋白原增加，巨幼细胞贫血与血清类黏蛋白水平升高相关。除伴有感染的缺铁性贫血治疗效果欠佳外，所有这些贫血的治疗效果均良好。
