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生物催化与生物转化的一扇窗口。

A window into biocatalysis and biotransformations.

作者信息

Coward-Kelly Guillermo, Chen Rachel Ruizhen

机构信息

Novozymes North America, Franklinton, North Carolina 27525, USA.

出版信息

Biotechnol Prog. 2007 Jan-Feb;23(1):52-4. doi: 10.1021/bp060358k.

Abstract

Eight papers were presented in this year's symposium "Advances in Biocatalysis" at the 232nd ACS National Meeting, accentuating the most recent development in biocatalysis. Researchers from both industry and academia are addressing several fundamental problems in biocatalysis, including the limited number of commercially available enzymes that can be provided in bulk quantities, the limited enzyme stability and activity in nonaqueous environments, and the permeability issue and cell localization problems in whole-cell systems. A trend that can be discerned from these eight talks is the infusion of new tools and technologies in addressing various challenges facing biocatalysis. Nanotechnology, bioinformatics, cellular membrane engineering and metabolic engineering (for engineering whole-cell catalysts), and protein engineering (to improve enzymes and create novel enzymes) are becoming more routinely used in research laboratories and are providing satisfactory solutions to the problems in biocatalysis. Significant progress in various aspects of biocatalysis from discovery to industrial applications was highlighted in this symposium.

摘要

在第232届美国化学学会全国会议上举行的今年“生物催化进展”研讨会上,有八篇论文发表,突出了生物催化领域的最新进展。来自工业界和学术界的研究人员正在解决生物催化中的几个基本问题,包括可大量提供的市售酶数量有限、酶在非水环境中的稳定性和活性有限,以及全细胞系统中的通透性问题和细胞定位问题。从这八场报告中可以看出一个趋势,即在应对生物催化面临的各种挑战时引入了新工具和技术。纳米技术、生物信息学、细胞膜工程和代谢工程(用于工程化全细胞催化剂)以及蛋白质工程(用于改进酶和创造新型酶)在研究实验室中越来越常用,并为生物催化中的问题提供了令人满意的解决方案。本次研讨会突出了生物催化从发现到工业应用各个方面的重大进展。

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