墨西哥13例申克孢子丝菌的流行病学数据及分子特征（线粒体DNA）
Epidemiological data and molecular characterization (mtDNA) of Sporothrix schenckii in 13 cases from Mexico.
作者信息
Arenas Roberto, Miller Daniel, Campos-Macias Pablo
机构信息
Department of Dermatology, Dr. Manuel Gea Gonzalez General Hospital, Mexico City.
出版信息
Int J Dermatol. 2007 Feb;46(2):177-9. doi: 10.1111/j.1365-4632.2006.03036.x.
BACKGROUND
Sporotrichosis is an endemic mycosis in Mexico and Central America.
OBJECTIVES
To present epidemiological data and characterize molecular subtypes of 13 strains of Sporothrix schenckii, and to correlate clinical and epidemiologic presentation with subtypes.
METHODOLOGY
Thirteen Mexican cases of sporotrichosis were identified, and mitochondrial DNA (mtDNA) from clinical isolates of S. schenckii were analyzed using RFLP Hae III. Molecular types 2, 3, 14, 28, and 29 were observed.
RESULTS
Clinical presentations and molecular types were consistent with established epidemiologic patterns for S. schenckii in this region.
CONCLUSIONS
This investigation provides further evidence of the strong regional specificity of molecular types of this organism.
背景
孢子丝菌病是墨西哥和中美洲的一种地方性真菌病。
目的
呈现13株申克孢子丝菌的流行病学数据并对其分子亚型进行特征分析，以及将临床和流行病学表现与亚型相关联。
方法
确定了13例墨西哥孢子丝菌病病例，并使用限制性片段长度多态性（RFLP）Hae III分析了申克孢子丝菌临床分离株的线粒体DNA（mtDNA）。观察到分子类型2、3、14、28和29。
结果
临床表型和分子类型与该地区已确立的申克孢子丝菌流行病学模式一致。
结论
本研究为该生物体分子类型的强区域特异性提供了进一步证据。
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