[骨形态发生蛋白在骨修复中的应用]

[Application of BMP to bone repair].

作者信息

Yamaguchi Akira

机构信息

Graduate School of Tokyo Medical and Dental University, Section of Oral Pathology.

出版信息

Clin Calcium. 2007 Feb;17(2):263-9.

PMID:17272885

Abstract

Bone regeneration process involves upregulation of various bone morphogenetic proteins (BMPs) and their receptors, and several lines of evidence have demonstrated that BMP signaling plays a crucial role in bone regeneration. Recent research using conditional knockout mice of BMP-2 in limb revealed the essential role of BMP-2 during bone regeneration. Recombinant human BMPs and gene therapy of BMPs have been successfully applied to bone repair including application to dental implant.

摘要

骨再生过程涉及多种骨形态发生蛋白（BMPs）及其受体的上调，并且多条证据表明BMP信号通路在骨再生中起关键作用。最近利用肢体中BMP-2条件性敲除小鼠进行的研究揭示了BMP-2在骨再生过程中的重要作用。重组人BMPs以及BMPs的基因治疗已成功应用于骨修复，包括应用于牙种植体。