Morag Iris, Goldman Michael, Kuint Jacob, Heyman Eli
Neonatal Intensive Care Unit, Assaf Harofeh Medical Center, Zerifin, Israel.
Isr Med Assoc J. 2007 Jan;9(1):24-7.
Necrotizing enterocolitis is a common progressive gastrointestinal disease affecting more than 5% of very low birth weight infants and associated with a high mortality rate.
To determine whether excessive weight gain in preterm infants is an early sign of NEC.
Seventeen preterm infants with perforated NEC were identified and matched with 17 control subjects for birth weight and gestational age. The postnatal age (days) at diagnosis of NEC was identified, and weight changes as well as clinical and laboratory data were recorded and compared for 7 days prior through 7 days post-diagnosis.
A significant difference in weight gain was noticed between D-1 and D 0. The NEC and control groups gained 5.1% and 1.2%, respectively (P = 0.002). None of the sick infants lost weight on days -1 to D 0.
Excessive weight gain was observed in premature infants who subsequently developed NEC. Daily evaluation of weight changes should be considered part of a strategy for early identification of infants at risk for developing NEC. Future studies are needed to confirm this finding in a prospective manner and to investigate its pathogenesis.
坏死性小肠结肠炎是一种常见的进行性胃肠道疾病，影响超过5%的极低出生体重儿，且死亡率很高。
确定早产儿体重过度增加是否为坏死性小肠结肠炎的早期迹象。
确定17例坏死性小肠结肠炎穿孔的早产儿，并与17名对照受试者在出生体重和胎龄方面进行匹配。确定坏死性小肠结肠炎诊断时的出生后年龄（天），记录诊断前7天至诊断后7天的体重变化以及临床和实验室数据并进行比较。
在诊断前1天（D-1）和诊断当天（D 0）之间观察到体重增加存在显著差异。坏死性小肠结肠炎组和对照组分别增加了5.1%和1.2%（P = 0.002）。在诊断前1天至诊断当天，患病婴儿均未出现体重减轻。
随后发生坏死性小肠结肠炎的早产儿出现了体重过度增加。每日评估体重变化应被视为早期识别有发生坏死性小肠结肠炎风险婴儿策略的一部分。需要未来的研究以前瞻性方式证实这一发现并研究其发病机制。
