Landgraf Ralf
University of California Los Angeles, Department of Medicine, Hematology-Oncology and Biological Chemistry, Molecular Biology Institute, Los Angeles, California 90095-1678, USA.
Breast Cancer Res. 2007;9(1):202. doi: 10.1186/bcr1633.
EGFR-type receptor tyrosine kinases achieve a broad spectrum of cellular responses by utilizing a set of structurally conserved building blocks. Based on available crystal structures and biochemical information, significant new insights have emerged into modes of receptor control, its deregulation in cancer, and the nuances that differentiate the four human receptors. This review gives an overview of current models of the control of receptor activity with a special emphasis on HER2 and HER3.
表皮生长因子受体（EGFR）型受体酪氨酸激酶通过利用一组结构保守的组件实现广泛的细胞反应。基于现有的晶体结构和生化信息，对于受体的调控模式、其在癌症中的失调以及区分四种人类受体的细微差别，已经有了重要的新见解。本综述概述了目前受体活性调控模型，特别强调了HER2和HER3。
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