The purpose of this investigation was to examine the influence of electrode placement over the estimated innervation zone (IZ) for the vastus lateralis, as well as proximal and distal to the estimated IZ, on the torque-related patterns for electromyographic (EMG) amplitude and mean power frequency (MPF) during concentric and eccentric isokinetic muscle actions of the leg extensors. Eleven men performed randomly ordered, submaximal to maximal concentric and eccentric isokinetic muscle actions of the dominant leg extensors in 10% increments from 10 to 90% peak torque (PT). Surface EMG signals were recorded simultaneously from the vastus lateralis muscle with bipolar electrode arrangements placed over the estimated IZ, as well as proximal and distal to the estimated IZ. The results indicated that there were no consistent differences among the proximal, IZ, and distal electrode placement sites for the patterns of responses for absolute and normalized EMG amplitude and MPF versus torque, or the mean absolute and normalized EMG amplitude and MPF values. Thus, these findings suggested that during concentric and eccentric isokinetic muscle actions of the leg extensors, electrode placement over the estimated IZ for the vastus lateralis had no effect on the patterns of responses or mean values for absolute and normalized EMG amplitude and MPF versus torque.