Pappo I, Karni T, Sandbank J, Dinur I, Sella A, Stahl-Kent V, Wasserman I, Halevy A
Comprehensive Breast Care Institute, Assaf Harofeh Medical Center, Zerifin 70300, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel.
Breast. 2007 Feb;16(1):60-7. doi: 10.1016/j.breast.2006.05.007.
The characteristics, menstrual risk factors and surgical therapy of 187 consecutive patients more than 70 years of age (mean: 75.9) were investigated and compared with those of 609 patients less than 70 years of age (mean: 53.9). There was no difference in stage, size, state of axillary nodes, grade, histological types, Ki-67, vascular invasion, estrogen receptor rate, and HER-2/neu (+) rate. Positive progesterone receptor rate was higher in older patients (54.7% vs. 63.1%). Tumors were larger (p=0.01) and their stage higher (p=0.014) in patients more than 80 years of age. All menstrual risk factors were similar in the two groups. Positive familial history was more frequent in patients <60 years. Significantly more young patients used hormone replacement therapy (HRT) (21.8 vs. 8.6%). Older patients underwent less breast-conserving surgery (36.1 vs. 55.1%), and less axillary lymph node dissection (ALND) (69.7 vs. 84.9%). We conclude that breast cancer characteristics and menstrual risk factors are similar in the two age groups.
对187例年龄超过70岁（平均75.9岁）的连续患者的特征、月经风险因素和手术治疗进行了调查，并与609例年龄小于70岁（平均53.9岁）的患者进行了比较。在分期、大小、腋窝淋巴结状态、分级、组织学类型、Ki-67、血管侵犯、雌激素受体率和HER-2/neu（+）率方面没有差异。老年患者的孕激素受体阳性率较高（54.7%对63.1%）。80岁以上患者的肿瘤更大（p=0.01），分期更高（p=0.014）。两组的所有月经风险因素相似。年龄<60岁的患者有家族史阳性的情况更常见。明显更多的年轻患者使用激素替代疗法（HRT）（21.8%对8.6%）。老年患者接受保乳手术的比例较低（36.1%对55.1%），腋窝淋巴结清扫术（ALND）的比例也较低（69.7%对84.9%）。我们得出结论，两个年龄组的乳腺癌特征和月经风险因素相似。
