环磷腺苷效应元件结合蛋白（Epac）与心血管系统
Epac and the cardiovascular system.
作者信息
Schmidt Martina, Sand Carsten, Jakobs Karl H, Michel Martin C, Weernink Paschal A Oude
机构信息
Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
出版信息
Curr Opin Pharmacol. 2007 Apr;7(2):193-200. doi: 10.1016/j.coph.2006.10.004. Epub 2007 Feb 2.
Exchange protein activated by cyclic AMP (Epac) -- a cyclic AMP-activated guanine nucleotide exchange factor for Ras-like GTPases -- has emerged as a novel mediator of pivotal processes in the cardiovascular system, including cellular calcium handling, hypertrophy, integrin-mediated cell adhesion, establishment of cell polarity, cell migration and endothelial barrier functioning. Epac controls these various cellular responses apparently by signaling to several effector proteins. Spatiotemporal dynamics in the subcellular distribution of Epac-driven signaling networks probably determine the net outcome of cyclic AMP signaling in the cardiovascular system.
环磷酸腺苷激活的交换蛋白（Epac）——一种针对类Ras GTP酶的环磷酸腺苷激活的鸟嘌呤核苷酸交换因子——已成为心血管系统中关键过程的新型介质，这些过程包括细胞钙处理、肥大、整合素介导的细胞粘附、细胞极性建立、细胞迁移和内皮屏障功能。Epac显然是通过向几种效应蛋白发出信号来控制这些不同的细胞反应。Epac驱动的信号网络在亚细胞分布中的时空动态可能决定了心血管系统中环磷酸腺苷信号的最终结果。
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