Poe Dennis S, Grimmer J Fredrik, Metson Ralph
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA.
Laryngoscope. 2007 Feb;117(2):231-7. doi: 10.1097/01.mlg.0000246227.65877.1f.
OBJECTIVE/HYPOTHESIS: Laser eustachian tuboplasty (LETP) combined with appropriate medical management will eliminate the chronic presence of middle ear effusions in selected patients.
The study population consisted of 13 adults with otitis media with effusion (OME). Patients underwent slow-motion video endoscopy to identify the location and extent of surgical resection. A diode or argon laser was used to vaporize areas of hypertrophic mucosa and submucosa along the cartilaginous eustachian tube. Patients were evaluated at 6, 12, and 24 months. Successful outcome was defined as absence of OME. Patients with evidence of reflux disease or allergic rhinitis were treated with medical therapy before surgery and throughout the follow-up period as indicated.
LETP combined with medical management eliminated OME in 36% (4 of 11) of patients at 6 months, 40% (4 of 10) at 1 year, and 38% (3 of 8) at 2 years. Failure of LETP correlated with presence of laryngopharyngeal reflux (P = .01) or allergic disease (P = .05) for the results at 1 year but not at 2 years.
LETP combined with appropriate medical management may be an effective treatment in select patients with chronic persistent eustachian tube dysfunction. A controlled trial with a larger number of subjects will be necessary to determine the efficacy of LETP and identify those factors predictive of successful outcome.
目的/假设:激光咽鼓管成形术(LETP)联合适当的药物治疗将消除部分患者中耳积液的长期存在。
研究对象为13例成人分泌性中耳炎(OME)患者。患者接受慢动作视频内镜检查以确定手术切除的位置和范围。使用二极管或氩激光汽化沿软骨性咽鼓管的肥厚黏膜和黏膜下区域。在6个月、12个月和24个月时对患者进行评估。成功的结果定义为无OME。有反流性疾病或过敏性鼻炎证据的患者在手术前及整个随访期间根据需要接受药物治疗。
LETP联合药物治疗在6个月时使36%(11例中的4例)的患者消除了OME,1年时为40%(10例中的4例),2年时为38%(8例中的3例)。LETP治疗失败与1年时的喉咽反流(P = .01)或过敏性疾病(P = .05)有关,但与2年时无关。
LETP联合适当的药物治疗可能是治疗部分慢性持续性咽鼓管功能障碍患者的有效方法。需要进行一项有更多受试者的对照试验,以确定LETP的疗效并确定那些预测成功结果的因素。