超氧阴离子在半胱胺加氧酶各种辅因子自氧化过程中的作用。
The involvement of superoxide anions in the autoxidation of various cofactors of cysteamine-oxygenase.
作者信息
Dupré S, Federici G, Santoro L, Rossi Fanelli M R, Cavallini D
出版信息
Mol Cell Biochem. 1975 Dec 31;9(3):149-54. doi: 10.1007/BF01751310.
The reduction of tetranitroblue tetrazolium with cysteamine, mediated by a number of dyes, elemental sulphur, elemental selenium and selenide, under aerobic conditions, was inhibited to various extent upon addition of superoxide dismutase. A strict parallelism between the ability to produce O2- ions and the property of those compounds to act as cofactors for cysteamine-oxygenase, to yield hypotaurine, has been observed. Based on the fact that the autoxidation of cysteamine also gives rise to O2- formation, though to a minor extent, we propose a mechanism for cysteamine-oxygenase action. This mechanism was derived from the data obtained in the model system studied.
在有氧条件下，由多种染料、元素硫、元素硒和硒化物介导的半胱胺对硝基蓝四氮唑的还原反应，在添加超氧化物歧化酶后受到不同程度的抑制。已经观察到产生超氧阴离子的能力与这些化合物作为半胱胺加氧酶的辅因子以产生次牛磺酸的性质之间存在严格的平行关系。基于半胱胺的自氧化也会产生超氧阴离子，尽管程度较小，我们提出了一种半胱胺加氧酶作用的机制。该机制源自所研究模型系统中获得的数据。
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