乌拉圭人群中HLA I类抗原以及HLA - A、- B和 - C单倍型频率

HLA class I antigen and HLA-A, -B, and -C haplotype frequencies in Uruguayans.

作者信息

Alvarez Ines, Bengochea Milka, Toledo Roberto, Carretto Elena, Hidalgo Pedro C

机构信息

Laboratorio de Inmunogenética e Histocompatibilidad, Instituto Nacional de Trasplante y Donación de Células, Tejidos y Organos (INDT), Hospital de Clinicas Manuel Quintela, Ave. Italia s/n Piso 4, CP 11600, Montevideo, Uruguay.

出版信息

Hum Biol. 2006 Aug;78(4):513-25. doi: 10.1353/hub.2006.0051.

DOI:10.1353/hub.2006.0051

PMID:17278625

Abstract

HLA class I antigens were determined for 959 unrelated Uruguayans. The predominant HLA alleles were A2, Cw4, and B35, and the most frequently observed two-loci haplotypes were A2-B44 and B35-Cw4. The most frequent three-loci HLA haplotype was A2-Cw5-B44. We compared the Uruguayan sample with similar data from other populations.

摘要

对959名无血缘关系的乌拉圭人进行了I类人类白细胞抗原（HLA）检测。主要的HLA等位基因是A2、Cw4和B35，最常观察到的两位点单倍型是A2 - B44和B35 - Cw4。最常见的三位点HLA单倍型是A2 - Cw5 - B44。我们将乌拉圭样本与其他人群的类似数据进行了比较。