Killackey Eóin, Yung Alison R
Department of Psychology, University of Melbourne, Australia.
Curr Opin Psychiatry. 2007 Mar;20(2):121-5. doi: 10.1097/YCO.0b013e328017f67d.
Over 15 years, early intervention in psychosis has grown to become a mainstream funded approach to clinical care. This review examines recent developments in evaluating the effectiveness of early intervention. It considers identification and treatment of those at risk of psychosis, as well as interventions in the post-onset phase of illness.
Development of methods identifying those at risk of psychosis continues to evolve. Promising results in the prevention and delay of transition to psychotic disorder from a high-risk state have been found. Psychological and psychosocial interventions are important components of these preventive programmes. Two recent meta-analyses indicate that there is a consistent relationship between duration of untreated psychosis and outcome independent of other factors. Further evidence shows that early intervention reduces the duration of untreated psychosis, produces better outcomes in terms of symptomatic and functional domains, and is cheaper than standard models of care.
There is evidence that early intervention is effective for early psychosis. Some challenges remain. These include developing a greater focus on functional recovery and prevention of relapse.
在过去15年中,精神病早期干预已发展成为临床护理中一种获得资金支持的主流方法。本综述探讨了评估早期干预效果的最新进展。它考虑了精神病风险人群的识别与治疗,以及疾病发作后阶段的干预措施。
识别精神病风险人群的方法仍在不断发展。在预防和延缓从高危状态转变为精神障碍方面已取得了有前景的结果。心理和社会心理干预是这些预防项目的重要组成部分。最近的两项荟萃分析表明,未治疗精神病的持续时间与结局之间存在独立于其他因素的一致关系。进一步的证据表明,早期干预可缩短未治疗精神病的持续时间,在症状和功能领域产生更好的结局,并且比标准护理模式更便宜。
有证据表明早期干预对早期精神病有效。但仍存在一些挑战。这些挑战包括更加关注功能恢复和预防复发。