Rooks Daniel S
Division of Rheumatology and the Center for the Study of Nutrition Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Curr Opin Rheumatol. 2007 Mar;19(2):111-7. doi: 10.1097/BOR.0b013e328040bffa.
Fibromyalgia is a common chronic pain disorder characterized by complex symptomatology and few consistently effective treatments. The purpose of this review is to highlight the recent literature from April 2005 through September 2006 involving treatment options.
Prior evidence suggests that medication and self-management approaches to care can improve symptoms, function and well-being in this patient population. Recent studies examining the efficacy of two serotonin and norepinephrine-reuptake inhibitors--duloxetine and milnacipran--and the anticonvulsant pregabalin are encouraging. Studies evaluating different forms of exercise continue to support the belief that increased physical activity is an essential component of any treatment plan for the patient with fibromyalgia. Three studies added to the understanding of treatment adherence. Finally, three studies evaluating the efficacy of acupuncture in the treatment of fibromyalgia showed conflicting results, but added to the knowledge needed for clinicians to have substantive conversations with patients.
Recent studies support the recommendation of a multimodal approach to treatment involving individualized, evidence-based pharmacotherapy and self-management. Treatment goals should include the improvement of symptoms, primarily pain and sleep, and the promotion of positive health behaviors with the aim of improving physical function and emotional well-being.
纤维肌痛是一种常见的慢性疼痛疾病,其症状复杂,且鲜有始终有效的治疗方法。本综述的目的是重点介绍2005年4月至2006年9月期间有关治疗选择的最新文献。
先前的证据表明,药物治疗和自我管理护理方法可改善该患者群体的症状、功能和健康状况。近期对两种5-羟色胺和去甲肾上腺素再摄取抑制剂(度洛西汀和米那普明)以及抗惊厥药普瑞巴林疗效的研究令人鼓舞。评估不同形式运动的研究继续支持这样一种观点,即增加身体活动是纤维肌痛患者任何治疗计划的重要组成部分。三项研究增进了对治疗依从性的理解。最后,三项评估针灸治疗纤维肌痛疗效的研究结果相互矛盾,但增加了临床医生与患者进行实质性交流所需的知识。
近期研究支持采用多模式治疗方法,包括个体化的循证药物治疗和自我管理。治疗目标应包括改善症状,主要是疼痛和睡眠,并促进积极的健康行为,以改善身体功能和情绪健康。