Utili R, Tripodi M F, Abernathy C O, Zimmerman H J, Gillespie J
Institute for Medical Therapy, University of Naples, Italy.
Proc Soc Exp Biol Med. 1992 Jan;199(1):49-53. doi: 10.3181/00379727-199-43327.
The present study has demonstrated that tauroursodeoxycholate (TUDC), but not taurocholate, can reverse chlorpromazine (CPZ)-induced cholestasis in the isolated perfused rat liver. At an infusion rate of 1.5 mumol/min, TUDC led to restoration of bile flow in the perfused rat liver made cholestatic by the addition of 250 microM CPZ. This reversal was accompanied by an increased excretion of CPZ and its metabolites. A higher infusion rate of 5.0 mumols TUDC/min, however, led to only a transient increase in bile flow and to no increase in CPZ excretion. In contrast to the effects of TUDC, infusion of taurocholate led to an exacerbation of CPZ-induced cholestasis. The differences in the efficacy of the two bile salts may be due to their relative detergent (hydrophobic) properties.
本研究表明，牛磺熊去氧胆酸（TUDC）而非牛磺胆酸可逆转氯丙嗪（CPZ）诱导的离体灌注大鼠肝脏胆汁淤积。以1.5 μmol/min的输注速率，TUDC可使因添加250 μM CPZ而胆汁淤积的灌注大鼠肝脏恢复胆汁流动。这种逆转伴随着CPZ及其代谢产物排泄增加。然而，5.0 μmol TUDC/min的较高输注速率仅导致胆汁流动短暂增加，且CPZ排泄未增加。与TUDC的作用相反，输注牛磺胆酸会加重CPZ诱导的胆汁淤积。两种胆汁盐疗效的差异可能归因于它们相对的去污剂（疏水性）特性。
