戊二醛会影响生物人工心脏瓣膜的生物相容性。
Glutaraldehyde affects biocompatibility of bioprosthetic heart valves.
作者信息
Grimm M, Eybl E, Grabenwöger M, Spreitzer H, Jäger W, Grimm G, Böck P, Müller M M, Wolner E
机构信息
Second Department of Surgery, University of Vienna, Austria.
出版信息
Surgery. 1992 Jan;111(1):74-8.
A marked release of glutaraldehyde from commercially available pericardial bioprosthetic heart valve (BHV) material in washing solutions was found by high performance liquid chromatography (up to 1.8 ppm of glutaraldehyde per gram of dry tissue). In vitro endothelial cell proliferation rate was impaired dose-dependently in the presence of increasing glutaraldehyde concentrations of the cultivation medium (r = 0.9; p less than 0.05). Cultivation of endothelial cells was impossible on the surface of commercially available BHV material, but successful and uninhibited when toxic glutaraldehyde ligands of the BHV material were antagonized by treatment with L-glutamic acid.
通过高效液相色谱法发现，市售心包生物人工心脏瓣膜（BHV）材料在清洗液中会大量释放戊二醛（每克干组织中戊二醛含量高达1.8 ppm）。在培养基中戊二醛浓度不断增加的情况下，体外内皮细胞增殖率呈剂量依赖性受损（r = 0.9；p < 0.05）。在市售BHV材料表面无法培养内皮细胞，但当用L-谷氨酸处理拮抗BHV材料的有毒戊二醛配体时，则可成功且不受抑制地培养内皮细胞。
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