Peters Stephan L M, Alewijnse Astrid E
Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Curr Opin Pharmacol. 2007 Apr;7(2):186-92. doi: 10.1016/j.coph.2006.09.008. Epub 2007 Feb 5.
Increasing evidence suggests a key role for the bioactive lipid sphingosine-1-phosphate (S1P) and its G-protein-coupled receptors (S1P(1-5)) in the cardiovascular system. Recent advances in sphingolipid research indicates that cardiomyocyte, vascular smooth muscle and endothelial cell function is greatly influenced by the relative expression and activity both of S1P receptors and of the enzymes involved in sphingolipid metabolism. For instance, the discovery and development of S1P receptor agonists such as FTY720 has clearly indicated the involvement of S1P receptors in the regulation of heart rate. In addition, sphingolipid metabolism induced, for example, by tumour necrosis factor-alpha or angiotensin II plays an important role in vessel structure, function and tone.
越来越多的证据表明，生物活性脂质鞘氨醇-1-磷酸（S1P）及其G蛋白偶联受体（S1P(1-5)）在心血管系统中起关键作用。鞘脂研究的最新进展表明，心肌细胞、血管平滑肌和内皮细胞功能受到S1P受体以及参与鞘脂代谢的酶的相对表达和活性的极大影响。例如，FTY720等S1P受体激动剂的发现和开发清楚地表明S1P受体参与心率调节。此外，例如由肿瘤坏死因子-α或血管紧张素II诱导的鞘脂代谢在血管结构、功能和张力中起重要作用。
