Li Ningjun, Li Guangbi
Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.
Am J Physiol Renal Physiol. 2025 Mar 1;328(3):F431-F443. doi: 10.1152/ajprenal.00193.2024. Epub 2025 Feb 11.
Sphingolipids are a family of bioactive lipids. The key components include ceramides, ceramide-1-phosphate, sphingosine, and sphingosine-1-phosphate. Sphingolipids were originally considered to be primarily structural elements of cell membranes but were later recognized as bioactive signaling molecules that play diverse roles in cellular behaviors such as cell differentiation, migration, proliferation, and death. Studies have demonstrated changes in key components of sphingolipids in the kidneys under different conditions and their important roles in the renal function and the pathogenesis of various kidney diseases. This review summarizes the most recent advances in the role of sphingolipid signaling in kidney diseases.
鞘脂是一类生物活性脂质。其关键成分包括神经酰胺、神经酰胺-1-磷酸、鞘氨醇和鞘氨醇-1-磷酸。鞘脂最初被认为主要是细胞膜的结构成分，但后来被确认为生物活性信号分子，在细胞分化、迁移、增殖和死亡等细胞行为中发挥多种作用。研究表明，在不同条件下肾脏中鞘脂的关键成分会发生变化，它们在肾功能和各种肾脏疾病的发病机制中具有重要作用。本综述总结了鞘脂信号在肾脏疾病中作用的最新进展。
