Kalix P, Roch P
Naunyn Schmiedebergs Arch Pharmacol. 1975;291(2):131-7. doi: 10.1007/BF00500045.
The cAMP content of the bovine superior cervical ganglion increases rapidly when the tissue is incubated in media containing high concentrations of potassium and theophylline. This effect of high K+ is mimicked by Rb+, Cs+ and NH4+. The depolarizing substances veratridine and ouabain also cause an increase in the concentration of ganglionic cAMP; the effect of ouabain develops more slowly than that of veratridine. Tetracaine, in high concentrations, reduces the response to potassium, whereas it reduces the response to veratridine at much lower concentrations. Tetrodotoxin, at a concentration that barely affects the response to potassium, prevents the response to veratridine.
当牛颈上神经节组织在含有高浓度钾和茶碱的培养基中孵育时，其环磷酸腺苷（cAMP）含量会迅速增加。高钾的这种作用可被铷离子、铯离子和铵离子模拟。去极化物质藜芦碱和哇巴因也会导致神经节cAMP浓度升高；哇巴因的作用比藜芦碱发展得更慢。高浓度的丁卡因会降低对钾的反应，而在低得多的浓度下它会降低对藜芦碱的反应。河豚毒素在几乎不影响对钾反应的浓度下，可阻止对藜芦碱的反应。
