Charalambides D, Segal I
Department of Surgery, Baragwanath Hospital, Johannesburg, South Africa.
Am J Gastroenterol. 1992 Jan;87(1):74-8.
Colonic pH is important in the regulation of colonic cell growth, control of absorption and secretion, and bile acid degradation, which may be a key step in the development of colon cancer. This study determined the mucosal, luminal, and fecal pH in right and left colons of otherwise healthy patients who underwent colostomies because of trauma. The pH was evaluated while patients consumed a western diet. In addition, the mucosal, luminal, and fecal pH in patients with colostomies carried out for colorectal cancer also was assessed. All patients were blacks--a low-risk group for colorectal cancer. The results showed that mucosal pH was alkaline (pH 8) and was similar on both sides of the colon of healthy colostomates and in colon cancer patients. Luminal pH (7.6) was the same in healthy right colostomates and cancer patients and was significantly lower that mucosal pH. Fecal pH was significantly lower in right colostomates (6.0) than in left (6.5), and in healthy right colostomates compared with colon cancer patients (6.6). In addition, fecal pH was significantly lower than mucosal and luminal pH.
结肠pH值在结肠细胞生长调节、吸收与分泌控制以及胆汁酸降解中起着重要作用，而胆汁酸降解可能是结肠癌发生发展的关键步骤。本研究测定了因创伤接受结肠造口术的健康患者左右结肠的黏膜、肠腔和粪便pH值。在患者食用西方饮食时对pH值进行评估。此外，还评估了因结直肠癌进行结肠造口术患者的黏膜、肠腔和粪便pH值。所有患者均为黑人——结直肠癌低风险人群。结果显示，黏膜pH值呈碱性（pH值为8），在健康结肠造口者和结肠癌患者的结肠两侧相似。健康右半结肠造口者和癌症患者的肠腔pH值（7.6）相同，且显著低于黏膜pH值。右半结肠造口者的粪便pH值（6.0）显著低于左半结肠造口者（6.5），且健康右半结肠造口者的粪便pH值低于结肠癌患者（6.6）。此外，粪便pH值显著低于黏膜和肠腔pH值。
