McNeil T F, Blennow G, Lundberg L
Department of Psychiatry, University of Lund, Malmö, Sweden.
Am J Psychiatry. 1992 Jan;149(1):57-61. doi: 10.1176/ajp.149.1.57.
Early somatic developmental anomalies may be one expression of a genetic influence toward psychosis. The purpose of this study was to investigate whether higher rates of early developmental anomalies are associated with heightened genetic risk for psychosis.
Rates of congenital malformations and minor structural developmental anomalies were prospectively investigated in 84 high-risk offspring of women with histories of psychosis of nonorganic origin (schizophrenic, schizoaffective, affective, and other psychoses) and in 100 offspring of demographically similar control women with no history of psychosis. Data were collected by means of multiple physical examinations through the first 3-4 years of the offspring's lives.
The rates of total congenital malformations were high, but the great majority of these malformations in both the index group and the control group represented minor physical aberrations. Rates of congenital malformations in the offspring of the index women (or any specific diagnostic subgroup of these women) were not different from those in the offspring of the control women.
The inferred genetic risk for psychosis does not appear to be associated with greater rates of early somatic developmental anomalies, suggesting that early developmental anomalies do not represent an expression of genetic influence toward psychosis.
早期躯体发育异常可能是遗传因素对精神病影响的一种表现形式。本研究旨在调查早期发育异常发生率较高是否与精神病的遗传风险增加有关。
前瞻性地调查了84名母亲有非器质性精神病病史（精神分裂症、分裂情感性障碍、情感性精神病及其他精神病）的高危后代以及100名人口统计学特征相似、无精神病病史的对照女性的后代中先天性畸形和轻微结构发育异常的发生率。通过在后代生命的前3至4年进行多次体格检查来收集数据。
先天性畸形的总发生率较高，但指数组和对照组中的绝大多数此类畸形均为轻微身体异常。指数组女性后代（或这些女性的任何特定诊断亚组）的先天性畸形发生率与对照组女性后代的发生率并无差异。
推测的精神病遗传风险似乎与早期躯体发育异常发生率较高无关，这表明早期发育异常并非遗传因素对精神病影响的一种表现形式。
