Andrews J C, Ator G A, Honrubia V
Division of Head and Neck Surgery, UCLA School of Medicine 90024-1624.
Arch Otolaryngol Head Neck Surg. 1992 Jan;118(1):74-8. doi: 10.1001/archotol.1992.01880010078020.
The pathophysiology of the characteristic episodic symptoms of vertigo, low-frequency hearing loss, and tinnitus in Menière's disease remains poorly understood. It is likely that the manifestation of this condition may be multifactorial and related to elements affecting the inner ear beyond the underlying pathology of endolymphatic hydrops. We have identified a subgroup of female patients with Menière's disease in which the symptoms of this disorder are correlated with the late luteal phase of the menstrual cycle (premenstrual period). Through audiometric and vestibular testing, we have documented these inner ear effects in six women. Although many hormonal effects occur during the premenstrual period, compartmental fluid redistribution within the body may be the most pertinent. Endolymphatic hydrops represents a fluid imbalance within the inner ear and, when combined with an additional fluid shift, may produce symptomatic dysfunction. Case histories demonstrating the correlation of the symptoms of Menière's disease and the premenstrual period will be presented along with theoretical mechanisms of pathophysiology.
梅尼埃病中眩晕、低频听力损失和耳鸣等特征性发作性症状的病理生理学仍未得到充分理解。这种疾病的表现可能是多因素的，并且与影响内耳的因素有关，而不仅仅是内淋巴积水的潜在病理。我们已经确定了一组患有梅尼埃病的女性患者，该疾病的症状与月经周期的黄体晚期（经前期）相关。通过听力测定和前庭测试，我们记录了6名女性的这些内耳影响。虽然在经前期会出现许多激素效应，但体内的隔室间液体重新分布可能是最相关的。内淋巴积水代表内耳内的液体失衡，当与额外的液体转移相结合时，可能会产生有症状的功能障碍。将展示梅尼埃病症状与经前期相关性的病例史以及病理生理学的理论机制。
