成年干细胞中神经可塑性的评估。
Evaluation of neural plasticity in adult stem cells.
作者信息
Ross Jeffrey J, Verfaillie Catherine M
机构信息
Stem Cell Institute, Cell Biology and Development, University of Minnesota Medical School, MN 55455, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):199-205. doi: 10.1098/rstb.2006.2021.
The role of stem cells has long been known in reproductive organs and various tissues including the haematopoietic system and skin. During the last decade, stem cells have also been identified in other organs, including the nervous system, both during development and in post-natal life. More recently, evidence has been presented that stem cells thought to be responsible for the generation of mature differentiated cells of one organ, such as haematopoietic stem cells, may have the ability to also differentiate across lineages and contribute to tissues other than haematopoietic cells, including neuronal tissue, suggesting that easily accessible stem cells sources may one day be useful in the therapy of ischaemic (stroke) and also degenerative diseases of the nervous system. Here, we will evaluate the validity of such claims based on a number of criteria we believe need to be fulfilled to definitively conclude that certain stem cells can give rise to functional neural cells that might be suitable for therapy of neural disorders.
干细胞在生殖器官以及包括造血系统和皮肤在内的各种组织中的作用早已为人所知。在过去十年中，人们还在包括神经系统在内的其他器官中发现了干细胞，无论是在发育过程中还是在出生后的生命阶段。最近，有证据表明，被认为负责生成某一器官成熟分化细胞的干细胞，如造血干细胞，可能也具有跨谱系分化的能力，并能为造血细胞以外的组织做出贡献，包括神经组织，这表明易于获取的干细胞来源有朝一日可能有助于治疗缺血性（中风）以及神经系统退行性疾病。在此，我们将根据一些标准来评估此类说法的有效性，我们认为要确凿地得出某些干细胞能够产生可能适用于治疗神经疾病的功能性神经细胞这一结论，这些标准是必须满足的。
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