载脂蛋白E-ε4与长期难治性颞叶癫痫患者记忆力减退有关。
ApoE-epsilon4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy.
作者信息
Busch R M, Lineweaver T T, Naugle R I, Kim K H, Gong Y, Tilelli C Q, Prayson R A, Bingaman W, Najm I M, Diaz-Arrastia R
机构信息
Department of Psychiatry & Psychology, Cleveland Clinic, 9500 Euclid Avenue, P57, Cleveland, OH 44195, USA.
出版信息
Neurology. 2007 Feb 6;68(6):409-14. doi: 10.1212/01.wnl.0000253021.60887.db.
OBJECTIVE
To investigate the relationship between the apolipoprotein (ApoE) epsilon4 allele and memory performance (verbal and nonverbal) in patients with medically intractable temporal lobe epilepsy (TLE) who underwent temporal lobectomy.
METHODS
Presurgical and postsurgical memory performance was examined in 87 adult patients with TLE (epsilon4 = 22; non-epsilon4 = 65) to determine whether the expression of ApoE-epsilon4 may be associated with memory performance in this population and to examine how this relationship may be affected by duration of epilepsy.
RESULTS
There was a significant interaction between ApoE-epsilon4 status and duration of epilepsy such that epsilon4 carriers with a long duration of epilepsy demonstrated the poorest memory performance on both verbal and nonverbal measures. This relationship was observed both before and after temporal lobectomy, with little change in test performance over time.
CONCLUSIONS
The ApoE-epsilon4 allele interacts with longstanding seizures to affect memory performance, both verbal and nonverbal, in patients with medically intractable temporal lobe epilepsy.
目的
研究接受颞叶切除术的药物难治性颞叶癫痫（TLE）患者中载脂蛋白（ApoE）ε4等位基因与记忆表现（言语和非言语）之间的关系。
方法
对87例成年TLE患者（ε4 = 22例；非ε4 = 65例）术前和术后的记忆表现进行检查，以确定ApoE-ε4的表达是否可能与该人群的记忆表现相关，并研究这种关系如何受到癫痫持续时间的影响。
结果
ApoE-ε4状态与癫痫持续时间之间存在显著交互作用，即癫痫持续时间长的ε4携带者在言语和非言语测量中记忆表现最差。这种关系在颞叶切除术前和术后均有观察到，测试表现随时间变化不大。
结论
ApoE-ε4等位基因与长期发作相互作用，影响药物难治性颞叶癫痫患者的言语和非言语记忆表现。
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