Suppr超能文献

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.

作者信息

Bernal Federico, Tyler Andrew F, Korsmeyer Stanley J, Walensky Loren D, Verdine Gregory L

机构信息

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

出版信息

J Am Chem Soc. 2007 Mar 7;129(9):2456-7. doi: 10.1021/ja0693587. Epub 2007 Feb 7.

Abstract
摘要

相似文献

1
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.
J Am Chem Soc. 2007 Mar 7;129(9):2456-7. doi: 10.1021/ja0693587. Epub 2007 Feb 7.
2
Design and synthesis of BRC analogous peptides and their interactions with a key p53 peptide.
FEBS Lett. 2018 Oct;592(20):3438-3445. doi: 10.1002/1873-3468.13256. Epub 2018 Oct 3.
3
4
Binding of Amphipathic Cell Penetrating Peptide p28 to Wild Type and Mutated p53 as studied by Raman, Atomic Force and Surface Plasmon Resonance spectroscopies.
Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):910-921. doi: 10.1016/j.bbagen.2017.01.022. Epub 2017 Jan 24.
5
Investigating peptide sequence variations for 'double-click' stapled p53 peptides.
Org Biomol Chem. 2014 Jun 28;12(24):4074-7. doi: 10.1039/c4ob00742e.
8
Interaction of the anticancer p28 peptide with p53-DBD as studied by fluorescence, FRET, docking and MD simulations.
Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):342-350. doi: 10.1016/j.bbagen.2018.11.003. Epub 2018 Nov 10.
9
Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.
Mol Cell Biol. 2004 Nov;24(22):10083-98. doi: 10.1128/MCB.24.22.10083-10098.2004.
10
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.
J Biol Chem. 2005 Mar 4;280(9):8051-9. doi: 10.1074/jbc.M411176200. Epub 2004 Dec 20.

引用本文的文献

1
Conformational modulation of intrinsically disordered transactivation domains for cancer therapy.
PNAS Nexus. 2025 May 9;4(5):pgaf152. doi: 10.1093/pnasnexus/pgaf152. eCollection 2025 May.
2
Recent Advances in Augmenting the Therapeutic Efficacy of Peptide-Drug Conjugates.
J Med Chem. 2025 May 8;68(9):9037-9056. doi: 10.1021/acs.jmedchem.5c00007. Epub 2025 Apr 23.
3
Raman active diyne-girder conformationally constrained p53 stapled peptides bind to MDM2 for visualisation without fluorophores.
RSC Chem Biol. 2025 Jan 15;6(3):394-403. doi: 10.1039/d4cb00288a. eCollection 2025 Mar 5.
4
Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics.
Chem Rev. 2024 Nov 27;124(22):13020-13093. doi: 10.1021/acs.chemrev.4c00423. Epub 2024 Nov 14.
5
Translation of Deoxyribonucleic Acid into Synthetic Alpha Helical Peptides for Darwinian Evolution.
JACS Au. 2024 Oct 2;4(10):4013-4022. doi: 10.1021/jacsau.4c00738. eCollection 2024 Oct 28.
6
Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors.
Nat Chem Biol. 2025 Feb;21(2):247-255. doi: 10.1038/s41589-024-01716-z. Epub 2024 Aug 30.
7
SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex.
J Am Chem Soc. 2024 Sep 11;146(36):25047-25057. doi: 10.1021/jacs.4c07920. Epub 2024 Aug 27.
8
Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers.
Res Sq. 2024 Jul 19:rs.3.rs-4644285. doi: 10.21203/rs.3.rs-4644285/v1.
9
Molecular Modeling of Single- and Double-Hydrocarbon-Stapled Coiled-Coil Inhibitors against Bcr-Abl: Toward a Treatment Strategy for CML.
J Phys Chem B. 2024 Jul 11;128(27):6476-6491. doi: 10.1021/acs.jpcb.4c02699. Epub 2024 Jul 1.
10
Biospecific Chemistry for Covalent Linking of Biomacromolecules.
Chem Rev. 2024 Jul 10;124(13):8516-8549. doi: 10.1021/acs.chemrev.4c00066. Epub 2024 Jun 24.

本文引用的文献

1
Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2.
J Am Chem Soc. 2006 Aug 30;128(34):11000-1. doi: 10.1021/ja063102j.
2
The P53 pathway: what questions remain to be explored?
Cell Death Differ. 2006 Jun;13(6):1027-36. doi: 10.1038/sj.cdd.4401910.
3
Solution structure of a beta-peptide ligand for hDM2.
J Am Chem Soc. 2005 Mar 30;127(12):4118-9. doi: 10.1021/ja042933r.
5
Use of a retroinverso p53 peptide as an inhibitor of MDM2.
J Am Chem Soc. 2004 Dec 22;126(50):16288-9. doi: 10.1021/ja044883w.
6
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
Science. 2004 Sep 3;305(5689):1466-70. doi: 10.1126/science.1099191.
7
Helical beta-peptide inhibitors of the p53-hDM2 interaction.
J Am Chem Soc. 2004 Aug 11;126(31):9468-9. doi: 10.1021/ja031625a.
8
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science. 2004 Feb 6;303(5659):844-8. doi: 10.1126/science.1092472. Epub 2004 Jan 2.
9
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.
Science. 2003 Dec 12;302(5652):1972-5. doi: 10.1126/science.1091362.
10
Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.
Nat Rev Cancer. 2003 Feb;3(2):102-9. doi: 10.1038/nrc991.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验