由Ti(O-i-Pr)4/MXn/Mg催化的烯丙基和炔丙基醚选择性裂解为醇的反应
Selective cleavage of allyl and propargyl ethers to alcohols catalyzed by Ti(O-i-Pr)4/MXn/Mg.
作者信息
Ohkubo Mutsumi, Mochizuki Sayaka, Sano Takeshi, Kawaguchi Yuuki, Okamoto Sentaro
机构信息
Department of Material & Life Chemistry, Kanagawa University, 3-27-1 Rokkakubashi, Yokohama 221-8686, Japan.
出版信息
Org Lett. 2007 Mar 1;9(5):773-6. doi: 10.1021/ol062963u. Epub 2007 Feb 7.
[reaction: see text] Allyl and propargyl ethers were effectively deallylated or depropargylated to the parent alcohols via a C-O bond cleavage catalyzed by a low-valent titanium reagent (LVT), Ti(O-i-Pr)4/TMSCl/Mg or Ti(O-i-Pr)4/MgBr2/Mg, under mild reaction conditions. Differentiation between the allyl and propargyl ethers was achieved by the reaction in the presence of AcOEt as an additive. The reagent also catalyzed intra- and intermolecular cyclotrimerization reactions of alkynes to substituted benzenes.
[反应：见正文] 在温和的反应条件下，烯丙基醚和炔丙基醚通过低价钛试剂（LVT）Ti(O-i-Pr)4/TMSCl/Mg或Ti(O-i-Pr)4/MgBr2/Mg催化的C-O键断裂，有效地脱烯丙基化或脱炔丙基化生成相应的醇。在乙酸乙酯作为添加剂存在下进行反应，实现了烯丙基醚和炔丙基醚之间的区分。该试剂还催化炔烃与取代苯的分子内和分子间环三聚反应。
Zotero 插件