Aldehyde-selective Wacker oxidation in a thiyl-mediated vinyl group transfer route to daunosamine.
作者信息
Friestad Gregory K, Jiang Tao, Mathies Alex K
机构信息
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
出版信息
Org Lett. 2007 Mar 1;9(5):777-80. doi: 10.1021/ol063010z. Epub 2007 Feb 7.
PMID:17284042
Abstract
[reaction: see text] Asymmetric dihydroxylation, thiyl radical mediated transfer of a silicon-tethered vinyl group to a hydrazone and an unconventional aldehyde-selective Wacker oxidation are sequenced for an efficient synthesis of methyl N-trifluoroacetyl-L-daunosaminide in 32% overall yield from crotonaldehyde.
摘要
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