小儿肾细胞癌的细胞遗传学研究结果

Cytogenetic findings in pediatric renal cell carcinoma.

作者信息

Soller Maria Johansson, Kullendorff Carl-Magnus, Békássy Albert N, Alumets Jan, Mertens Fredrik

机构信息

Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden.

出版信息

Cancer Genet Cytogenet. 2007 Feb;173(1):75-80. doi: 10.1016/j.cancergencyto.2006.09.018.

DOI:10.1016/j.cancergencyto.2006.09.018

PMID:17284375

Abstract

Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that are similar to their adult counterparts.

摘要

肾腺癌是罕见的儿童肿瘤。仅报道过30例伴有染色体异常的病例，除了一组以X染色体异常为特征的特殊乳头状肿瘤外，其核型特征及其发病机制背后的分子机制均不清楚。我们对来自两例儿童肾癌（一例乳头状和一例嫌色肾细胞癌）的短期培养细胞进行了细胞遗传学分析，揭示了以下核型：58 - 60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22和36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1 - 2r。这些发现表明，儿童肾细胞癌的亚群显示出与其成人对应物相似的核型。