Desai Rahul A, Assimos Dean G
Department of Urology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Curr Opin Urol. 2007 Mar;17(2):104-8. doi: 10.1097/MOU.0b013e328011bce5.
Recent studies in nephrolithiasis have investigated why stones form, improvements in medical therapy, and advances in surgical therapy. We outline recent research in these areas.
We describe a series of articles characterizing the histopathology of Randall's plaques and the renal papillae in patients with nephrolithiasis, detailing genetic discoveries related to uric acid stones, describing further uses of alpha-antagonists in nephrolithiasis, and reporting improvements in extracorporeal shockwave lithotripsy technique and outcomes.
Characterization of the renal papillae and Randall's plaques in different types of stones may guide the urologist in treating stones and may lead to further research into how and where stones of different compositions form.
近期关于肾结石的研究探讨了结石形成的原因、药物治疗的改进以及手术治疗的进展。我们概述了这些领域的最新研究。
我们描述了一系列文章，这些文章对肾结石患者的兰德尔斑和肾乳头的组织病理学进行了特征描述，详细介绍了与尿酸结石相关的基因发现，描述了α受体拮抗剂在肾结石治疗中的进一步应用，并报告了体外冲击波碎石术技术和治疗效果的改善。
不同类型结石中肾乳头和兰德尔斑的特征描述可能会指导泌尿外科医生治疗结石，并可能引发对不同成分结石的形成方式和部位的进一步研究。
