一种对映选择性布朗斯特酸催化的烯胺曼尼希反应。
An enantioselective Brønsted acid catalyzed enamine Mannich reaction.
作者信息
Tillman A Louise, Dixon Darren J
机构信息
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
出版信息
Org Biomol Chem. 2007 Feb 21;5(4):606-9. doi: 10.1039/b616143j. Epub 2006 Dec 22.
DOI:10.1039/b616143j
PMID:17285167
Abstract
An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H(8)-BINOL has been identified as the optimal catalyst, to afford versatile beta-amino aryl ketones in good yield and enantiomeric excess.
摘要
已开发出一种对映选择性布朗斯特酸催化的苯乙酮衍生烯胺与N - 叔丁氧羰基亚胺之间的曼尼希反应。简单二醇（S）-H（8）-联萘酚已被确定为最佳催化剂，能以良好的产率和对映体过量得到多种β-氨基芳基酮。
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