替莫唑胺治疗对多巴胺激动剂耐药的侵袭性催乳素瘤
Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists.
作者信息
Neff Lisa M, Weil Michelle, Cole Alan, Hedges Thomas R, Shucart William, Lawrence Donald, Zhu Jay-Jiguang, Tischler Arthur S, Lechan Ronald M
机构信息
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts-New England Medical Center, Boston, MA 02111, USA.
出版信息
Pituitary. 2007;10(1):81-6. doi: 10.1007/s11102-007-0014-1.
Prolactinomas are common tumors of the anterior pituitary gland. While conventional therapies, including dopamine agonists, transsphenoidal surgery and radiotherapy, are usually effective in controlling tumor growth, some patients develop treatment-resistant tumors. In this report, we describe a patient with an invasive prolactinoma resistant to conventional therapy that responded to the administration of the alkylating agent, temozolomide.
催乳素瘤是常见的垂体前叶肿瘤。虽然包括多巴胺激动剂、经蝶窦手术和放疗在内的传统疗法通常能有效控制肿瘤生长，但一些患者会出现对治疗耐药的肿瘤。在本报告中，我们描述了一名侵袭性催乳素瘤患者，该患者对传统治疗耐药，但对烷化剂替莫唑胺的给药有反应。
Zotero 插件