Hofmann M P, Gbureck U, Duncan C O, Dover M S, Barralet J E
Biomaterials Unit, School of Dentistry, University of Birmingham, Birmingham B4 6NN, UK.
J Biomed Mater Res B Appl Biomater. 2007 Oct;83(1):1-8. doi: 10.1002/jbm.b.30761.
This study investigated the use of partially set hydroxyapatite forming calcium phosphate cement as a carvable and mechanically stable bone substitute material. Hydroxyapatite-forming cements were made of either mechanically activated alpha-tricalcium phosphate or a mixture of tetracalcium phosphate and dicalcium phosphate anhydrous and setting was arrested up to 4 h post setting. The study showed that these partially set rigid samples of defined geometry could be carved into a desired shape when the degree of reaction was 30-40% and the relative porosity between 40 and 50%; samples are then expected to set completely after implantation in the presence of water or serum, having the same compressive strength as a continuously set calcium phosphate cement (up to 36 MPa). The development of compressive strength, phase composition, and crystallinity when varying production parameters of these partially "preset" bone substitute materials are presented for both cement systems.
本研究调查了部分凝固的羟基磷灰石形成型磷酸钙骨水泥作为一种可雕刻且机械性能稳定的骨替代材料的应用。羟基磷灰石形成型骨水泥由机械活化的α - 磷酸三钙或磷酸四钙与无水磷酸二钙的混合物制成，凝固后4小时内凝固过程可被阻止。研究表明，当反应程度为30 - 40%且相对孔隙率在40%至50%之间时，这些具有特定几何形状的部分凝固刚性样品可被雕刻成所需形状；样品在植入有水或血清的环境中后预计会完全凝固，其抗压强度与连续凝固的磷酸钙骨水泥相同（高达36兆帕）。针对这两种骨水泥体系，展示了在改变这些部分“预设定”骨替代材料的生产参数时抗压强度、相组成和结晶度的变化情况。
