银杏叶对硫代乙酰胺诱导的大鼠暴发性肝衰竭的保护作用。
Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats.
作者信息
Harputluoglu M M M, Demirel U, Ciralik H, Temel I, Firat S, Ara C, Aladag M, Karincaoglu M, Hilmioglu F
机构信息
Department of Gastroenterology, Inonu University Medical Faculty, Malatya, Turkey.
出版信息
Hum Exp Toxicol. 2006 Dec;25(12):705-13. doi: 10.1177/0960327106073827.
Gingko biloba (GB) has antioxidant and platelet-activating factor (PAF) antagonistic effects. We investigated the protective effects of GB on thioacetamide (TAA)-induced fulminant hepatic failure in rats. Fulminant hepatic failure was induced in treatment groups by three intraperitoneal (ip) injections of TAA (350 mg/kg) at 24-hour intervals. Treatments with GB (100 mg/kg per day, orally) and N-acetylcysteine (20 mg/kg twice daily, sc) were initiated 48 hours prior to TAA administration. The liver was removed for histopathological examinations. Serum and liver thiobarbituric acid-reactive substance (TBARS) levels were measured for assessment of oxidative stress. Liver necrosis and inflammation scores and serum and liver TBARS levels were significantly higher in the TAA group compared to the control group (P < 0.001, < 0.001, 0.001, < 0.001, respectively). Liver necrosis and inflammation scores and liver TBARS levels were significantly lower in the GB group compared to the TAA group (P < 0.001, < 0.001 and 0.01, respectively). GB ameliorated hepatic damage in TAA-induced fulminant hepatic failure. This may be due to the free radical-scavenging effects of GB.
银杏叶（GB）具有抗氧化和血小板活化因子（PAF）拮抗作用。我们研究了GB对硫代乙酰胺（TAA）诱导的大鼠暴发性肝衰竭的保护作用。在治疗组中，每隔24小时腹腔注射（ip）三次TAA（350mg/kg）以诱导暴发性肝衰竭。在给予TAA前48小时开始用GB（每天100mg/kg，口服）和N-乙酰半胱氨酸（20mg/kg，每日两次，皮下注射）进行治疗。取出肝脏进行组织病理学检查。测量血清和肝脏硫代巴比妥酸反应性物质（TBARS）水平以评估氧化应激。与对照组相比，TAA组的肝坏死和炎症评分以及血清和肝脏TBARS水平显著更高（分别为P<0.001、<0.001、0.001、<0.001）。与TAA组相比，GB组的肝坏死和炎症评分以及肝脏TBARS水平显著更低（分别为P<0.001、<0.001和0.01）。GB改善了TAA诱导的暴发性肝衰竭中的肝损伤。这可能归因于GB的自由基清除作用。
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