Hadsell Darryl, George Jessy, Torres Daniel
USDA Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030, USA.
J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):59-70. doi: 10.1007/s10911-007-9038-4.
In most species the functional activity of the mammary gland during lactation follows a biphasic developmental pattern. This pattern starts with a rapid increase in milk output that occurs with secretory activation and continues with a more gradual increase until the point of peak lactation is reached. Following this gain-of-function phase, the ability of the gland to produce milk decreases. This decrease occurs even if the lactation is prolonged by the presence of continued suckling stimulus and complete milk removal. This review describes the current state of our knowledge concerning the factors that regulate milk synthesis capacity by the mammary gland during the lactation cycle. The review describes four potential alternatives as mechanisms governing the process, which we refer to as secretory diminution. These alternatives are not presented as mutually exclusive of each other or other possible mechanisms, but are proposed as potential contributing mechanisms.
在大多数物种中，乳腺在哺乳期的功能活动遵循双相发育模式。这种模式始于随着分泌激活而出现的乳汁产量快速增加，并持续以更缓慢的速度增加，直至达到泌乳高峰期。在这个功能增强阶段之后，乳腺产生乳汁的能力下降。即使通过持续的哺乳刺激和完全排空乳汁来延长哺乳期，这种下降仍会发生。本综述描述了我们目前对哺乳期乳腺调节乳汁合成能力的因素的认识状况。该综述描述了作为控制这一过程的机制的四种潜在可能性，我们将其称为分泌减少。这些可能性并非相互排斥或与其他可能的机制相互排斥，而是作为潜在的促成机制提出的。
