缓慢延迟整流钾电流（IKs）与复极储备
Slow delayed rectifier potassium current (IKs) and the repolarization reserve.
作者信息
Jost Norbert, Papp Julius Gy, Varró András
机构信息
Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary.
出版信息
Ann Noninvasive Electrocardiol. 2007 Jan;12(1):64-78. doi: 10.1111/j.1542-474X.2007.00140.x.
Abstract
The aim of this review is to present the properties of the slow component of the delayed rectifier potassium current (IKs) in the human ventricle. The review gives a detailed description of the physiology, molecular biology and pharmacology of the IKs current, including kinetic properties, genetic structures, agonists and antagonists. The authors also present the role of the IKs current in the human cardiac repolarization focusing on several pathophysiological situations, such as the LQT syndrome and the Torsade de Pointes arrhythmia.
摘要
本综述的目的是介绍人类心室中延迟整流钾电流（IKs）慢成分的特性。该综述详细描述了IKs电流的生理学、分子生物学和药理学，包括动力学特性、基因结构、激动剂和拮抗剂。作者还阐述了IKs电流在人类心脏复极中的作用，重点关注几种病理生理情况，如长QT综合征和尖端扭转型室性心动过速。
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