心脏肥大的失代偿：细胞机制与新型治疗靶点
Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets.
作者信息
Diwan Abhinav, Dorn Gerald W
机构信息
Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA.
出版信息
Physiology (Bethesda). 2007 Feb;22:56-64. doi: 10.1152/physiol.00033.2006.
PMID:17289931
Abstract
Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.
摘要
心脏肥大可导致心力衰竭，这两种情况最终都可能是致命的。在此，将在生理、细胞和分子水平上描述与肥大和心力衰竭相关的传统及新机制。还将讨论如何将这些机制方面的考量合理应用于针对肥大和心力衰竭的治疗。
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